Am Rev Respir Dis 148: 1194–1203īowton DL, Kong D L (1989) High tidal volume ventilation produces increased lung water in oleic acid-injured rabbit lungs. J Appl Physiol 66: 2364–2368ĭreyfussl D, Saumon G (1993) Role of tidal volume, FRC and end-inspiratory volume in the development of pulmonary edema following mechanical ventilation. Hernandez LA, Peevy KJ, Moise AA, Parker JC (1989) Chest wall restriction limits high airway pressure-induced lung injury in young rabbits. Respective effects of high airway pressure, high tidal volume and positive end-expiratory pressure. J Appl Physiol 69: 577–583ĭreyfussl D, Soler P, Basset G, Saumon G (1988) High inflation pressure pulmonary edema. Am Rev Respir Dis 142: 321–328Ĭarlton D, Cummings JJ, Scheerer RG, Poulain FR, Bland RD (1990) Lung overexpansion increases pulmonary microvascular protein permeability in young lambs. Role of increased microvascular filtration pressure and permeability. Parker JC, Hernandez LA, Longenecker GL, Peevy K, Johnson W (1990) Lung edema caused by high peak inspiratory pressures in dogs. J Physiol 260: 409–424ĭreyfussl D, Basset G, Soler P, Saumon G (1985) Intermittent positive-pressure hyperventilation with high inflation pressures produces pulmonary microvascular injury in rats. J Appl Physiol 57: 1809 1816Įgan EA, Nelson RM, Olver RE (1976) Lung inflation and alveolar permeability to non-electrolytes in the adult sheep in vivo. Parker JC, Townsley MI, Rippe B, Taylor AE, Thigpen 1 (1984) Increased microvascular permeability in dog lungs due to high peak airway pressures. Tsuno K, Prato P, Kolobow T (1990) Acute lung injury from mechanical ventilation at moderately high airway pressures. Kolobow T, Moretti MP, Fumagalli R, Mascheroni D, Prato P, Chen V, Joris M (1987) Severe impairment in lung function induced by high peak airway pressure during mechanical ventilation. Protection by positive end-expiratory pressure. Webb HH, Tierney DF (1974) Experimental pulmonary edema due to intermittent positive pressure ventilation. Pingleton SK (1988) Complications of acute respiratory failure. This process is experimental and the keywords may be updated as the learning algorithm improves. These keywords were added by machine and not by the authors. These abnormalities may culminate in the production of a pulmonary permeability-type edema accompanied by diffuse alveolar damage. In addition to these “macroscopic” alterations, it has been experimentally demonstrated that lung distension during mechanical ventilation may induce alterations of lung fluid balance, increases in endothelial and epithelial permeability and severe ultrastructural damage. Barotrauma is the usual term for such complications and refers to the presence of extra-alveolar air (manifesting as interstitial emphysema, pneumomediastinum or pneumoperitoneum, pneumothorax, etc.). Of these adverse effects, some are the direct consequence of pulmonary pressure and/or volume changes induced by mechanical insufflation of diseased lungs. Mechanical ventilation is a technique which, although frequently life-saving, carries nevertheless the potential risk of severe complications.
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